The Human Exposome

The Human Exposome refers to the totality of environmental exposures over a lifetime from conception to adulthood.

It shifts our approach to studying the environment from the traditional ‘one exposure, one disease’ framework to a more holistic approach that explores multiple environmental factors affecting health.

The exposome is comprised of three overlapping domains: the personal, external and internal exposome. The personal exposome contains one person’s exposure to chemical pollutants, behavioural and lifestyle factors. The external exposome includes urban, built and transport settings, natural and green spaces, social aspects and climate. The internal exposome implies the biological responses to the personal and external exposome, including metabolism, epigenetics, aging, gut microbiota and stress.

The Human Exposome

The Human Exposome refers to the totality of environmental exposures over a lifetime from conception to adulthood.

It shifts our approach to studying the environment from the traditional ‘one exposure, one disease’ framework to a more holistic approach that explores multiple environmental factors affecting health.

The exposome is comprised of three overlapping domains: the personal, external and internal exposome. The personal exposome contains onea person’s exposure to chemical pollutants, behavioural and lifestyle factors. The external exposome includes urban, built and transport settings, natural and green spaces, social aspects and climate. The internal exposome implies the biological responses to the personal and external exposome, including metabolism, epigenetics, aging, gut microbiota and stress.

The Human Exposome

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