Scientific publications
Publications from the ATHLETE project explore a wide range of environmental exposures – including urban, chemical, lifestyle, and social risk factors – during pregnancy, childhood, and adolescence. The research examines how these early-life exposures shape biological responses and influence cardiometabolic, respiratory, and mental health in children.
Browse ATHLETE’s publications by category:
- Full exposome and child health
- Chemical Exposome and child health
- Urban exposome and child health
- Determinants, trends, and sources of the exposome
- Omics signatures related to the exposome
- Reviews, evidence synthesis, impact assessment
- Statistical methods
- Data infrastructure and federated data analysis
- Other biomarkers and child health outcomes
Full exposome and child health
- Amine I et al. (2025). Early-life exposome and health-related immune signatures in childhood. Environment International 109668.
- Guimbaud JB et al. (2024). Machine learning-based health environmental-clinical risk scores in European children. Communications Medicine 4(98).
- Amine I et al. (2023). Environmental exposures in early-life and general health in childhood. Environmental Health 22(53).
- Cáceres A et al. (2023). Prenatal environmental exposures associated with sex differences in childhood obesity and neurodevelopment. BMC Medicine 21(142).
Chemical Exposome and child health
1. Pregnancy and birth outcomes
- Blaauwendraad SM et al. (2025). Periconception bisphenol and phthalate concentrations in women and men, time to pregnancy, and risk of miscarriage. Environmental Research 278:121712.
- Jedynak P et al. (2025). Prenatal Exposure to Synthetic Phenols Assessed in Multiple Urine Samples and Dysregulation of Steroid Hormone Homeostasis in Two European Cohorts. Environmental Health Perspectives 133(5):57011.
- Blaauwendraad SM et al. (2024). Fetal bisphenol and phthalate exposure and early childhood growth in a New York City birth cohort. Environment International 187:108726.
- Knox B et al. (2024). Prenatal exposure to per- and polyfluoroalkyl substances, fetoplacental hemodynamics, and fetal growth. Environment International 193:109090.
- Jovanovic N et al. (2024). Associations between synthetic phenols, phthalates, and placental growth/function: a longitudinal cohort with exposure assessment in early pregnancy. Human Reproduction Open 2024(2):hoae018.
- van den Dries et al. (2021). Prenatal Exposure to Nonpersistent Chemical Mixtures and Fetal Growth: A Population-Based Study. Environmental Health Perspectives 129(11).
- Santos S et al. (2021). Maternal phthalate urine concentrations, fetal growth and adverse birth outcomes. A population-based prospective cohort study. Environment International 151: 106443.
- Sol CM et al. (2021). Maternal bisphenol urine concentrations, fetal growth and adverse birth outcomes: A population-based prospective cohort. Environmental Health 20(1).
2. Cardiometabolic health & puberty
- Sol CM et al. (2025). Fetal exposure to phthalates and body mass index from infancy to adolescence. The Generation R study. Environmental Research 274:121253.
- Bommarito PA et al. (2024). Prenatal Exposure to Nonpersistent Chemicals and Fetal-to-childhood Growth Trajectories. Epidemiology 35:6.
- Stevens DR et al. (2024). Gestational organophosphate pesticide exposure and childhood cardiovascular outcomes. BMC Pediatr 25:1.
- Blaauwendraad SM et al. (2024). Associations of bisphenol and phthalate exposure and anti-Mullerian hormone levels in women of reproductive age. EClinicalMedicine 74.
- Guil-Oumrait N et al. (2024). Prenatal Exposure to Chemical Mixtures and Metabolic Syndrome Risk in Children. JAMA Netw Open 7(5):e2412040.
- Freire C et al. (2024). Association of prenatal exposure to phthalates and synthetic phenols with pubertal development in three European cohorts. International Journal of Hygiene and Environmental Health 261:114418.
- Montazeri P et al. (2023). Prenatal Exposure to Multiple Endocrine-Disrupting Chemicals and Childhood BMI Trajectories in the INMA Cohort Study. Environmental Health Perspectives 131(10).
- Rouxel E et al. (2023). Prenatal exposure to multiple persistent organic pollutants in association with adiposity markers and blood pressure in preadolescents. Environment International 178:108056.
- Cano-Sancho G et al. (2023). Nutritional Modulation of Associations between Prenatal Exposure to Persistent Organic Pollutants and Childhood Obesity: A Prospective Cohort Study. Environmental Health Perspectives 131(3).
- Blaauwendraad SM et al. (2023). Fetal Organophosphate Pesticide Exposure and Child Adiposity Measures at 10 Years of Age in the General Dutch Population. Environmental Health Perspectives 131(8).
- Blaauwendraad SM et al. (2022). Maternal Phthalate and Bisphenol Urine Concentrations during Pregnancy and Early Markers of Arterial Health in Children. Environmental Health Perspectives 130(4).
- Sol CM et al. (2022). Prenatal Exposure to Phthalates and Bisphenols and Childhood Kidney Function: A Prospective Cohort Study. Exposure and Health 15.
- Guil-Oumrait N et al. (2022). Prenatal exposure to mixtures of phthalates and phenols and body mass index and blood pressure in Spanish preadolescents. Environment International 169: 107527.
- Sol CM et al. (2020). Associations of maternal phthalate and bisphenol urine concentrations during pregnancy with childhood blood pressure in a population-based prospective cohort study. Environment International 138: 105677.
- Sol CM et al. (2020). Fetal exposure to phthalates and bisphenols and childhood general and organ fat. A population-based prospective cohort study. International Journal of Obesity 44(11): 3070565.
- Sol CM et al. (2020). Fetal phthalates and bisphenols and childhood lipid and glucose metabolism. A population-based prospective cohort study. Environment International 144: 106063.
- Stratakis N et al. (2020). Association of Fish Consumption and Mercury Exposure During Pregnancy with Metabolic Health and Inflammatory Biomarkers in Children. JAMA Netw Open 3(3): e201007.
3. Neurodevelopment
- Brennan Kearns P et al. (2025). Mixtures of chemicals in pregnancy and their effects on cognitive and fine motor abilities in childhood. Environmental research 278:121712.
- Fabbri L et al. (2024). Childhood exposure to non-persistent endocrine disruptors, glucocorticosteroids, and attentional function: A cross-sectional study based on the parametric g-formula. Environmental Research 264:120413.
- Brennan Kearns P et al. (2024). Association of exposure to mixture of chemicals during pregnancy with cognitive abilities and fine motor function of children. Environment International 185:108490.
- Sarzo B et al. (2024). The impact of prenatal mercury on neurobehavioral functioning longitudinally assessed from a young age to pre-adolescence in a Spanish birth cohort. Environmental Research 118954.
- Ghassabian A et al. (2023). Prenatal exposure to common plasticizers: a longitudinal study on phthalates, brain volumetric measures, and IQ in youth. Molecular Psychiatry 28:4814-4822.
- Notario-Barandiaran L et al. (2023). Latent Childhood Exposure to Mixtures of Metals and Neurodevelopmental Outcomes in 4–5-Year-Old Children Living in Spain. Exposure and Health.
- Sprong C et al. (2023). A case study of neurodevelopmental risks from combined exposures to lead, methyl-mercury, inorganic arsenic, polychlorinated biphenyls, polybrominated diphenyl ethers and fluoride. International Journal of Hygiene and Environmental Health 251:114167.
- Soler-Blasco R et al. (2023). Genetic Susceptibility to Neurotoxicity Related to Prenatal Inorganic Arsenic Exposure in Young Spanish Children. Environ Sci Technol 57:15366−15378.
- Chatterjee M et al. (2022). Cadmium exposures and deteriorations of cognitive abilities: estimation of a reference dose for mixture risk assessments based on a systematic review and confidence rating. Environmental Health 21(69).
- de Leeuw V et al. (2022). Neuronal differentiation pathways and compound-induced developmental neurotoxicity in the human neural progenitor cell test (hNPT) revealed by RNA-seq. Chemosphere 304: 135298.
- Sarzo B et al. (2021). Maternal Perfluoroalkyl Substances, Thyroid Hormones, and DIO Genes: A Spanish Cross-sectional Study. Environmental Science & Technology 55(16).
4. Respiratory health and allergies
- Guillien A et al. (2025). Early-life exposure to mixture of phenols and respiratory health in pre-school children. European Respiratory Journal.
- Karramass T et al. (2023). Bisphenol and phthalate exposure during pregnancy and the development of childhood lung function and asthma. The Generation R Study. Environmental Pollution 332:121853.
- Abellan A et al. (2022). In utero exposure to bisphenols and asthma, wheeze, and lung function in school-age children: a prospective meta-analysis of 8 European birth cohorts. Environment International 162: 107178.
- Maritano S et al. (2022). Maternal pesticides exposure in pregnancy and the risk of wheezing in infancy: A prospective cohort study. Environment International 163: 107229.
- Lemire P et al. (2022). Association between household cleaning product profiles evaluated by the Ménag’Score® index and asthma symptoms among women from the SEPAGES cohort. International Archives of Occupational and Environmental Health 95.
5. Multi-outcome
- Amine I et al. (2025). Early-life exposure to mixtures of endocrine-disrupting chemicals and a multi-domain health score in preschool children. Environmental Research 272:121172.
Urban exposome and child health
1. Pregnancy and birth outcomes
- Cadman T et al. (2024). Urban environment in pregnancy and postpartum depression: An individual participant data meta-analysis of 12 European birth cohorts. Environment International 185:108453.
- Essers E et al. (2024). Ambient air temperature exposure and foetal size and growth in three European birth cohorts. Environment International 186:108619.
2. Cardiometabolic health
- Warkentin S et al. (2025). Ambient air pollution and childhood obesity from infancy to late childhood: An individual participant data meta-analysis of 10 European birth cohorts. Environment International 200:109527.
- Valente B et al. (2025). Residential exposure to green and blue spaces over childhood and cardiometabolic health outcomes: The generation XXI birth cohort. Environment International 198:109452.
- Liu M et al. (2024). Longitudinal associations of air pollution and green space with cardiometabolic risk factor clustering among children in the Netherlands. Environ Int 190.
- Descarpentrie A et al. (2024). Urban environment exposures, energy balance-related behaviors and their combination in preschoolers from three European countries. Environment International 190:108880.
- Gonçalves Soares A et al. (2024). Prenatal Urban Environment and Blood Pressure Trajectories From Childhood to Early Adulthood. JACC: Advances 3(2).
- Mölenberg FJM et al. (2021). Socioeconomic inequalities in the food environment and body composition among school-aged children: a fixed-effects analysis. International Journal of Obesity 45:2554–2561.
3. Neurodevelopment
- López-Vicente M et al. (2025). Long-Term Exposure to Traffic-Related Air Pollution and Noise and Dynamic Brain Connectivity across Adolescence. Environmental Health Perspectives 133(5):57002.
- Gómez-Herrera L et al. (2025). Air pollution and fetal brain morphological development: a prospective cohort study. The Lancet Planetary Health 9(6):e480-e490.
- Essers E et al. (2025). Exposure to high temperature and sleep in preadolescents from two European birth cohorts. Environment International 200:109543.
- Essers E et al. (2025). Temperature Exposure and Psychiatric Symptoms in Adolescents From 2 European Birth Cohorts. JAMA Netw Open 8(1):e2456898.
- Alfajarín Monfort I et al. (2024). Exposure to noise at home, emotional behaviour, and attention deficit hyperactivity disorder in 9-year-old children. An Sist Sanit Navar 47(2):e1079.
- Binter AC et al. (2024). Urban environment during pregnancy and childhood and white matter microstructure in preadolescence in two European birth cohorts. Environmental Pollution 346.
- Binter AC et al. (2024). Urban environment during pregnancy, cognitive abilities, motor function, and externalizing and internalizing symptoms at 2–5 years old in 3 Canadian birth cohorts. Environment International 195:109222.
- Kusters MSW et al. (2024). Residential ambient air pollution exposure and the development of white matter microstructure throughout adolescence. Environmental Research 262:119828.
- Crooijmans K et al. (2024). Nitrogen dioxide exposure, attentional function, and working memory in children from 4 to 8 years: Periods of susceptibility from pregnancy to childhood. Environment International 186.
- Fernandes A et al. (2023). Availability, accessibility, and use of green spaces and cognitive development in primary school children. Environmental Pollution 334:122143.
4. Respiratory health
- Maritano S et al. (2025). Exposure to climate change-related extreme events in the first year of life and occurrence of infant wheezing. Environment international 196:109303.
- Abellan A et al. (2024). Urban environment during pregnancy and lung function, wheezing, and asthma in school-age children. The generation R study. Environmental Pollution 344:123345.
- Guillien A et al. (2023). Associations between combined urban and lifestyle factors and respiratory health in European children. Environmental Research 242:117774.
- Marsal A et al. (2023). Prenatal Exposure to PM 2.5 Oxidative Potential and Lung Function in Infants and Preschool-Age Children: A Prospective Study. Environmental Health Perspectives 131.1:017004.
- Lepeule J et al. (2023). Pre-natal exposure to NO2 and PM2. 5 and newborn lung function: An approach based on repeated personal exposure measurements. Environmental Research 2023;226:115656.
5. Multi-outcome
- Fernandes A et al. (2024). Green spaces and respiratory, cardiometabolic, and neurodevelopmental outcomes: An individual-participant data meta-analysis of >35.000 European children. Environment International 190:108853.
Social and lifestyle exposome and child health
- Sanguesa J et al. (2025). Role of Maternal Vitamin D3 Levels in Shaping Adolescent Vascular Health: Evidence From a Spanish Population‐Based Birth Cohort. Journal of the American Heart Association 14(5).
- D’Errico A et al. (2025). Maternal occupational exposures during early stages of pregnancy and adverse birth outcomes in the NINFEA birth-cohort. PLoS One 14;20(1):e0313085.
- Cadman T et al. (2025). Social inequalities in child mental health trajectories: a longitudinal study using birth cohort data 12 countries. BMC Public Health 24(1).
- Barry KM et al. (2024). Early childcare arrangements and children’s internalizing and externalizing symptoms: an individual participant data meta-analysis of six prospective birth cohorts in Europe. The Lancet Regional Health – Europe 45:101036.
- Warkentin S et al. (2024). Dietary patterns among European children and their association with adiposity-related outcomes: a multi-country study. International Journal of Obesity.
- González L et al. (2024). Socioeconomic position, family context, and child cognitive development. European Journal of Pediatrics.
- Notario-Barandiaran L et al. (2023). Association between Mediterranean diet and metal(loid) exposure in 4-5-year-old children living in Spain. Environmental Research 233:116508.
- Descarpentrie A et al. (2023). Lifestyle patterns in European preschoolers: Associations with socio-demographic factors and body mass index. Pediatr Obes 18:e13079.
Determinants, trends and sources of the exposome
- Warkentin S et al. (2025). Dietary patterns and exposure to non-persistent endocrine-disrupting chemicals during pregnancy. Environment International.
- Samuelsson K et al. (2025). A comprehensive GPS-based analysis of activity spaces in early and late pregnancy using the ActMAP framework. Health & Place 91:103413.
- Pizzi C et al. (2024). Socioeconomic position during pregnancy and pre-school exposome in children from eight European birth cohort studies. Social Science & Medicine 359:117275.
- Moccia L et al. (2023). Modelling socioeconomic position as a driver of the exposome in the first 18 months of life of the NINFEA birth cohort children. Environment International 173:107864.
- Cserbik D et al. (2023). Concentrations of per- and polyfluoroalkyl substances (PFAS) in paired tap water and blood samples during pregnancy. J Expo Sci Environ Epidemiol.
- Lopez-Gonzalez U et al. (2023). Exposure to mercury among Spanish adolescents: Eleven years of follow-up. Environmental Research 231(Pt 2):116204.
Omics signatures related to the exposome
1. Multi-omics
- Stratakis N et al. (2025). Multi-omics architecture of childhood obesity and metabolic dysfunction uncovers biological pathways and prenatal determinants. Nature Communications 16:654.
- Wang C et al. (2025). Meet-in-the-middle meets multi-omics identifying molecular signatures of environmental drivers of childhood overweight. Environ Int 202.
- Maitre L et al. (2023). Integrating -omics approaches into population-based studies of endocrine disrupting chemicals: A scoping review. Environmental Research 228:115788.
- Fabbri L et al. (2023). Childhood exposure to non-persistent endocrine disrupting chemicals and multi-omic profiles: A panel study. Environment International 173:107856.
- Maitre L et al. (2022). Multi-omics signatures of the human early life exposome. Nature Communications 13:7024.
- Cosin-Tomas M et al. (2022). Prenatal Maternal Smoke, DNA Methylation, and Multi-omics of Tissues and Child Health. Current Environmental Health Reports 9: 502-512.
- Gallego-Paüls M et al. (2021). Variability of multi-omics profiles in a population-based child cohort. BMC Medicine 19 (1).
- Vives-Usano M et al. (2020). In utero and childhood exposure to tobacco smoke and multi-layer molecular signatures in children. BMC Medicine 18 (1).
2. Metabolomics
- Stachulski AV et al. (2025). Dietary substances and their glucuronides: structures, occurrence and biological activity. Natural Products Reports.
- Balcells C et al. (2023). Blurred lines: Crossing the boundaries between the chemical exposome and the metabolome. Current Opinion in Chemical Biology 78:102407.
- Stratakis N et al. (2022). Urinary metabolic biomarkers of diet quality in European children are associated with metabolic health. eLife 11:e71332.
- Blaauwendraad SM et al. (2021). Associations of maternal bisphenol urine concentrations during pregnancy with neonatal metabolomic profiles. Metabolomics 17(84).
3. Epigenetics
- Cosin-Tomas M et al. (2025). Association of exposure to second-hand smoke during childhood with blood DNA methylation. Environment International 195
- Hoang T T et al. (2025). Prenatal Smoking Exposures and Epigenome-wide Methylation in Newborn Blood Environmental Health Perspectives. Environmental Health Perspectives.
- Aguilar-Lacasaña S et al. (2025). Epigenome-wide association study of pregnancy exposure to green space and placental DNA methylation. Environmental Research 274:121286.
- Llauradó-Pont J et al. (2025). A meta-analysis of epigenome-wide association studies of ultra-processed food consumption with DNA methylation in European children. Clin Epigenet 17(3).
- Cilleros-Portet A et al. (2025). Potentially causal associations between placental DNA methylation and schizophrenia and other neuropsychiatric disorders. Nature Communications 16:2431.
- Das S et al. (2024). Air pollution exposure is associated with gene expression in children. Environ Epigenetics.
- Diez-Ahijado L et al. (2024). Evaluating the association between placenta DNA methylation and cognitive functions in the offspring. Translational Psychiatry 14:383.
- Aguilar-Lacasaña S et al. (2024). Green space exposure and blood DNA methylation at birth and in childhood – A multi-cohort study. Environment International 188:108684.
- Sol CM et al. (2022). Fetal exposure to phthalates and bisphenols and DNA methylation at birth: the Generation R Study. Clinical Epigenetics 14.
- Isaevska E et al. (2022). Prenatal exposure to PM10 and changes in DNA methylation and telomere length in cord blood. Environmental Research 209: 112717.
- Carreras-Gallo N et al. (2022). The early-life exposome modulates the effect of polymorphic inversions on DNA methylation. Communications Biology 455(2022).
- Wang C et al. (2022). Genetic regulation of newborn telomere length is mediated and modified by DNA methylation. Frontiers in Genetics 13:934277.
- Ruiz-Arenas C et al. (2022). Identification of autosomal cis expression quantitative trait methylation (cis eQTMs) in children’s blood. eLife 11:e65310.
- Lozano M et al. (2021). DNA methylation changes associated with prenatal mercury exposure: A meta-analysis of prospective cohort studies from PACE consortium. Environmental Research 204:112093.
4. Biological aging and allostatic load
- Mou Y et al. (2025). Outdoor air pollution, road traffic noise, and allostatic load in children aged 6-11 years: evidence from six European cohorts. Eur J Epidemiol 40(5).
- Wang C et al. (2025). The multi-omics signatures of telomere length in childhood. BMC Genomics 26(1):75.
- Lozano et al. (2024). Early life exposure to mercury and relationships with telomere length and mitochondrial DNA content in European children. Science of the Total Environment 932:173014.
- Marques I et al. (2023). Associations of green and blue space exposure in pregnancy with epigenetic gestational age acceleration. Epigenetics 18(1):2165321.
- Robinson O et al. (2023). Associations of four biological age markers with child development: A multi-omic analysis in the European HELIX cohort. eLife 12:e85104.
- Prado-Bert P et al. (2021). The early-life exposome and epigenetic age acceleration in children. Environment International 155.
5. Proteins
- de Prado-Bert P et al. (2022). Short- and medium-term air pollution exposure, plasmatic protein levels and blood pressure in children. Environmental Research 2011:113109.
6. Microbiome
- McCartney AL et al. (2025). Host interactions of bioactive molecules produced by Klebsiella spp. Microbiota and Host 3(1):e240011.
- Shah SN et al. (2024). Cerebrovascular damage caused by the gut microbe/host co-metabolite p-cresol sulfate is prevented by blockade of the EGF receptor. Gut Microbes 16(1).
- Pérez-Castro S et al. (2024). Influence of perinatal and childhood exposure to tobacco and mercury in children’s gut microbiota. Frontiers in Microbiology 14:1258988.
- Porru S et al. (2024). The effects of heavy metal exposure on brain and gut microbiota: A systematic review of animal studies. Environmental Pollution 348.
- Walker AW et al. (2023). Human microbiome myths and misconceptions. Nature Microbiology 8(8).
- Stachulski AV et al. (2022). A host-gut microbial amino acid co-metabolite, p-cresol glucuronide, promotes blood-brain barrier integrity in vivo. Tissue Barriers e2073175-2.
- Hoyles L et al. (2021). Regulation of blood–brain barrier integrity by microbiome-associated methylamines and cognition by trimethylamine N-oxide. Microbiome 9:235.
- Hu et al. (2021). A population-based study on associations of stool microbiota with atopic diseases in school-age children. The Journal of Allergy and Clinical Immunology 148(2).
7. Genetics
- Bustamante M, Balagué-Dobón L et al. (2024). Common genetic variants associated with urinary phthalate levels in children: A genome-wide study. Environment International 190:108845.
- Dack K et al. (2023). Genome-Wide Association Study of Blood Mercury in European Pregnant Women and Children. genes 14:2123.
- Soler-Blasco R et al. (2023). Influence of genetic polymorphisms on arsenic methylation efficiency during pregnancy: Evidence from a Spanish birth cohort. Science of The Total Environment 900:165740.
- Balagué-Dobón L et al. (2022). Fully exploiting SNP arrays: a systematic review on the tools to extract underlying genomic structure. Briefings in Bioinformatics bbac043.
- Fuentes-Paez G et al. (2022). Study of the Combined Effect of Maternal Tobacco Smoking and Polygenic Risk Scores on Birth Weight and Body Mass Index in Childhood. Frontiers in Genetics 13: 867611.
- Calvo-Serra B et al. (2020). Urinary metabolite quantitative trait loci in children and their interaction with dietary factors. Human Molecular Genetics 29(23).
Reviews, evidence synthesis, impact assessment
- Colzin S et al. (2024). A plausibility database summarizing the level of evidence regarding the hazards induced by the exposome on children health. International Journal of Hygiene and Environmental Health 256:114311.
- Wies B et al. (2024). Urban environment and children’s health: An umbrella review of exposure response functions for health impact assessment. Environmental Research 263:120084.
- Rocabois A et al. (2024) Chemical exposome and children health: identification of dose-response relationships from meta-analyses and epidemiological studies. Environmental Research 119811.
- Fernandes A et al. (2023). School‐Based Interventions to Support Healthy Indoor and Outdoor Environments for Children: A Systematic Review. International Journal of Environmental Research and Public Health 20(3):1746.
- Yang T et al. (2023). Interventions to Reduce Exposure to Synthetic Phenols and Phthalates from Dietary Intake and Personal Care Products: a Scoping Review. Current Environmental Health Reports.
- Guillien A et al. (2023). The exposome concept: how has it changed our understanding of environmental causes of chronic respiratory diseases? Breathe 19(2):230044.
- Vrijheid M et al. (2021). Advancing tools for human early life-course exposome research and translation (ATHLETE) – project overview. Environmental Epidemiology 5: e166.
Statistical methods
- Moccia C et al. (2024). Machine learning in causal inference for epidemiology. European journal of epidemiology 39 (10).
- Pan S et al. (2024). Applications of mixture methods in epidemiological studies investigating the health impact of persistent organic pollutants exposures: a scoping review. J Expo Sci Environ Epidemiol 35:522–534.
- Babin E et al. (2024). Opportunities offered by latent-based multiblock strategies to integrate biomarkers of chemical exposure and biomarkers of effect in environmental health studies. Chemosphere 361:142465.
- Goodrich J A et al. (2024). Integrating Multi-Omics with environmental data for precision health: A novel analytic framework and case study on prenatal mercury induced childhood fatty liver disease. Environment International 190:108930.
- Anguita-Ruiz A et al. (2023). Beyond the single-outcome approach: A comparison of outcome-wide analysis methods for exposome research. Environment International 182:108344.
- Warembourg C et al. (2023). Statistical Approaches to Study Exposome-Health Associations in the Context of Repeated Exposure Data: A Simulation Study. Environ. Sci. Technol.
- Babin E et al. (2023). A review of statistical strategies to integrate biomarkers of chemical exposure with biomarkers of effect applied in omic-scale environmental epidemiology. Environmental Pollution 330: 121741.
- Maitre L et al. (2022). State-of-the-art methods for exposure-health studies: Results from the exposome data challenge event. Environment International 168: 107422.
- Guillien A et al. (2021). The Exposome Approach to Decipher the Role of Multiple Environmental and Lifestyle Determinants in Asthma. International Journal of Environmental Research and Public Health 18 (3).
- Cadiou S et al. (2021). Performance of approaches relying on multidimensional intermediary data to decipher causal relationships between the exposome and health: A simulation study under various causal structures. Environment International 153: 106509.
- Escriba-Montagut X et al. (2021). Software Application Profile: exposomeShiny: a Toolbox for exposome data analysis. International Journal of Epidemiology dyab220.
- Santos S et al. (2020). Applying the exposome concept in birth cohort research: a review of statistical approaches. European Journal of Epidemiology 35 (3): 193–204.
Data infrastructure and federated data analysis
- Avraam D et al. (2025). DataSHIELD: mitigating disclosure risk in a multi-site federated analysis platform. Bioinformatics Advances 5(1): vbaf046.
- Budin-Ljøsne I et al. (2024). Participant engagement and involvement in longitudinal cohort studies: qualitative insights from a selection of pregnancy and birth, twin, and family-based population cohort studies. BMC Medical Research Methodology 24:297.
- Cadman T et al. (2024). MOLGENIS Armadillo: a lightweight server for federated analysis using DataSHIELD. Bioinformatics.
- Escriba-Montagut X et al. (2024). Federated privacy-protected meta- and mega-omics data analysis in multi-center studies with a fully open-source analytic platform. PLOS Computational Biology 20(12): e1012626.
- Schmitt CP et al. (2023). A roadmap to advance exposomics through federation of data. Exposome 3(1).
- Avraam D et al. (2022). A deterministic approach for protecting privacy in sensitive personal data. BMC Medical Informatics and Decision Making 22 (24).
- Swertz M et al. (2022). Towards an Interoperable Ecosystem of Research Cohort and Real-world Data Catalogues Enabling Multi-center Studies. Yearbook of Medical Informatics 31(01):262-272.
- Escribà-Montagut X et al. (2022). Software Application Profile: ShinyDataSHIELD—an R Shiny application to perform federated non-disclosive data analysis in multicohort studies. International Journal of Epidemiology dyac201.
- Marcon Y et al. (2021). Orchestrating privacy-protected big data analyses of data from different resources with R and DataSHIELD. PLOS Computational Biology 17(3): e1008880.
- Avraam D et al. (2021). Privacy preserving data visualizations. EPJ Data Science 10(2).
Other biomarkers and child health outcomes
- Gonçalves R et al. (2025). Early-life growth and emotional, behavior and cognitive outcomes in childhood and adolescence in the EU child cohort network: individual participant data meta-analysis of over 109,000 individuals. The Lancet Regional Health – Europe 52:101247.
- Blaauwendraad SM et al. (2025). Associations of fetal and infant growth with pubertal timing. Archives of Disease in Childhood 110:539-544.
- Huizing AHJ et al. (2025). Predicting obesity at adolescence from an early age in a Dutch observational cohort study: the development and internal validation of a multivariable prediction model. BMC Pediatr 25:1.
- Heesbeen E J et al. (2024). A systematic approach to identify gaps in neuroimmunology: TNF-α and fear learning deficits, a worked example. Brain, Behavior, and Immunity 123:752-764.
- Boxem AJ et al. (2024). Preconception and Early-Pregnancy Body Mass Index in Women and Men, Time to Pregnancy, and Risk of Miscarriage. JAMA Netw Open 7(9):e2436157.
- Wu T et al. (2024). Abdominal fat and risk of impaired lung function and asthma in children: A population-based prospective cohort study. Pediatric Allergy and Immunology 35(2):e14079.
- Wu T et al. (2024). Body composition and respiratory outcomes in children: a population-based prospective cohort study. Thorax 79(5).
- Gonçalves R et al. (2024). Associations of fetal and infant growth patterns with behavior and cognitive outcomes in early adolescence. JCPP Advances 2024:e12278.
- Gonçalves R et al. (2024). Arterial Health Markers in Relation to Behavior and Cognitive Outcomes at School Age. Journal of the American Heart Association 13:e029771.
- Dypas L B et al. (2023). Blood miRNA levels associated with ADHD traits in children across six European birth cohorts. BMC Psychiatry 23:696.
- Quezada-Pinedo HG et al. (2023). Maternal hemoglobin and iron status in early pregnancy and risk of respiratory tract infections in childhood: A population-based prospective cohort study. Pediatric Allergy and Immunology 34(9):e14025.
- Wu T et al. (2022). Visceral adiposity and respiratory outcomes in children and adults: a systematic review. International Journal of Obesity 46:1083-1100.
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